Article Summary

Title : Reconstructing synaptic background activity from conductance measurements in vivo
Authors : Quan Zou, Michelle Rudolph, Noah Roy, Maria V Sanchez-Vives, Diego Contreras and Alain Destexhe
Year : 2004
Journal : Neurocomputing
Volume : 65
Pages : 673-678

Abstract

To reconstruct synaptic background activity, we combined computational models with intracellular recordings in vivo. A new conductance analysis method applied to intracellular recordings in the somatosensory cortex of anesthetized rats revealed mirror changes of excitation and inhibition during the up- and down-states of slow waves, but concerted changes in conductance variances. We then used these measurements to constrain the patterns of random release at excitatory and inhibitory synapses in computational models. We show that measurements of the mean and variance of conductances are suf?cient constraints to design models fully consistent with in vivo recordings