Since the fusion of the UNIC with the Paris-Saclay Institute of Neuroscience - UMR 9197 Neuro-PSI, this site is no longer being updated.
You will find all the information about the ICN - ex-UNIC - directly on the Neuro-PSI website.
Article Summary

Title : Minimal Hodgkin–Huxley type models for different classes of cortical and thalamic neurons
Authors : Martin Pospischil, Maria Toledo-Rodriguez, Cyril Monier, Zuzanna Piwkowska, Thierry Bal, Yves Frégnac, Henry Markram and Alain Destexhe
Year : 2008
Journal : Biological Cybernetics
Volume : 99
Pages : 427-441


We review here the development of Hodgkin– Huxley (HH) type models of cerebral cortex and thalamic neurons for network simulations. The intrinsic electrophy- siological properties of cortical neurons were analyzed from several preparations, andwe selected the fourmost prominent electrophysiological classes of neurons. These four classes are “fast spiking”, “regular spiking”, “intrinsically bursting” and “low-threshold spike” cells. For each class, we ?t “mini- mal” HH type models to experimental data. The models contain the minimal set of voltage-dependent currents to account for the data. To obtain models as generic as possible, we used data from different preparations in vivo and in vitro, such as rat somatosensory cortex and thalamus, guinea-pig visual and frontal cortex, ferret visual cortex, cat visual cor- tex and cat association cortex. For two cell classes, we used automatic ?tting procedures applied to several cells, which revealed substantial cell-to-cell variability within each class. The selection of such cellular models constitutes a necessary step towards building network simulations of the thalamo- cortical system with realistic cellular dynamical properties.