Title : Noradrenaline and plasticity of the visual cortex of the kitten: a reexamination
Authors : Joelle Adrien, P Buisseret, Yves Frégnac, E Gary-Bobo, Michel Imbert, Jean Pol Tassin and Yves Trotter
Year : 1982
Journal : C R Seances Acad Sci III
Volume : 295
Pages : 745-50
We have undertaken a study of the role of the noradrenergic system in the functional modifications, observed in the primary visual cortex of the Kitten, following monocular deprivation. The lids of one eye were sutured in 5 week old Kittens for a period of 1 or 2 weeks. Noradrenergic depletion was obtained by 6-OHDA injection, either intraventricular or localized in the coeruleus complex. Our results indicate that disappearance of noradrenaline in area 17 does not prevent the loss of binocularity of cortical cells, but appears to limit ocular dominance shifts at a stage equivalent to that observed in the intact Kitten after 6 days of monocular deprivation.