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Overview of the Unit
Best Publications

The major publications made by the 5 interdisciplinary groups composing UNIC during the last 10 years have been classified in 4 fields, ranging from Systems Neuroscience, Computational Neuroscience and Neuroinformatics, Hybrid cybernetics and Physics applied to Neural Network Dynamics. The group leaders (Vision: Y. Frégnac; Haptic sense: D. Shulz; Electroreception and communication: K. Grant; Hybrid technology: T. Bal; Computational Neuroscience: A. Destexhe) are shown in bold type. In addition we have listed high profile interdisciplinary reviews made by the UNIC members on the theme of Complexity in Neural Network Dynamics.


The major publications made during the last 4 years are shown in pale blue.

Field 1: Complexity in Systems Neuroscience

Frégnac, Y. (1998). Homeostasis or synaptic plasticity ? Nature. 391: 845-846.

Graham, L.J., Monier, C. and Frégnac, Y. (1998). Visual input evokes transient and strong shunting inhibition in visual cortical neurons. Nature. 393: 369-374.

Bringuier, V., Chavane, F., Glaeser, L. and Frégnac, Y. (1999). Horizontal propagation of visual activity in the synaptic integration field of area 17 neurons. Science. 283: 695-699.

Frégnac, Y. (1999). A tale of the two spikes: when forward distal input meets backpropagation  Nature Neurosci.  2(4): 299-301.

Han, V. Z., Grant, K. and Bell, C. C. (2000). Reversible associative depression and non-associative potentiation at a parallel fiber synapse.  Neuron. 27: 611-622.

Shulz, D. E., Sosnik, R., Ego, V., Haidarliu, S. and Ahissar, E. (2000). A neuronal analogue of state-dependent learning. Nature. 403: 549-553.

Graham, L. J. (2001). The computation of directional selectivity in the retina occurs prior to the ganglion cell.  Nature Neurosci. 4: 176-182.

Monier, C., Chavane, F., Baudot, P., Graham, L. and Frégnac, Y. (2003). Orientation and direction selectivity of excitatory and inhibitory inputs in visual cortical neurons: a diversity of combinations produces spike tuning. Neuron. 37: 663-680.

Meek, J., Kirchberg, G., Grant, K. and von der Emde, G. (2004). Dye coupling without gap junctions suggests excitatory connections of GABAergic neurons. J. Comp. Neurol. 468: 151-154.

Ego-Stengel, V., Mello e Souza, T., Jacob V. and Shulz, D.E. (2005). Spatiotemporal characteristics of neuronal sensory integration in the barrel cortex of the rat. J. Neurophysiol. 93 : 1450-1467.

Lorenceau, J., Giersch, A., Seriès, P. (2005). Dynamics of competition between contour integration and contour segmentation. Vision Research. 45(1): 103-116.

Rudolph, M., Pelletier, J-G., Paré, D. and Destexhe, A. (2005). Characterization of synaptic conductances and integrative properties during electrically-induced EEG-activated states in neocortical neurons in vivo. J. Neurophysiol. 94: 2805-2821.

Davison, A.P. and Frégnac, Y. (2006). Learning crossmodal spatial transformations through spike-timing-dependent plasticity. J. Neurosci. 26: 5604-5615.

Jacob, V., Brazier, D.J., Erchova, J., Feldman, D. and Shulz, D. (2007). Spike-timing dependent synaptic depression in the in vivo barrel cortex of the rat. J. Neurosci. 27:1271-1284.

Rudolph, M., Pospischil, M., Timofeev, I. and Destexhe, A. (2007). Inhibition determines membrane potential dynamics and controls action potential generation in awake and sleeping cat cortex. J. Neurosci. 27: 5280-5290.

Van den Burg, E., Engelmann, J.P., Bacelo, J., Gomez, L. and Grant, K. (2007).  Etomidate reduces initiation of backpropagating dendritic action potentials: implications for sensory processing and synaptic plasticity during anesthesia. J. Neurophysiol. 97(3): 2373-2384.

Monier, C., Fournier, J. and Frégnac, Y. (2008). In vitro and in vivo measures of evoked excitatory and inhibitory conductance dynamics in sensory cortices. J. Neurosci. Methods. 169(2): 323-365.

Jacob, V., Le Cam, JL, Ego-Stengel, V. and Shulz, D. (2008). Emergent properties of tactile scenes selectively activate barrel cortex neurons. Neuron. 60 : 1112-1125.

Nadim, F., Brezina, V., Destexhe, A. and Linster, C. (2008). State dependence of network output: Modeling and experiments. J. Neurosci. 28: 11806-11813.

Bacelo, J., Engelmann, J., Hollmann M., Von der Emde, G. and Grant, K. (2008). Functional foveae in an electrosensory system. J. Comp. Neurol., (in press).

Monier C., Lucas-Meunier E., M. Amar, G. Baux, Y. Frégnac and P. Fossier. (in press) Involvement of nicotinic and muscarinic receptors in the endogenous cholinergic modulation of the balance between excitation and inhibition in the young rat visual cortex. Cerebral Cortex.

Field 2: Computational Neuroscience and Neuroinformatics

Rudolph, M. and Destexhe, A. (2003). A fast-conducting, stochastic integrative mode for neocortical neurons in vivo. J. Neurosci. 23: 2466-2476.

Rudolph, M. and Destexhe, A. (2005) An extended analytic expression for the membrane potential distribution of conductance-based synaptic noise. Neural Computation. 17: 2301-2315.

Rudolph, M. and Destexhe, A. (2006) Integrate-and-fire neurons with high-conductance state dynamics for event-driven simulation strategies. Neural Computation. 18: 2146-2210.

Davison, A. and Frégnac, Y. (2006). Learning crossmodal spatial transformations through spike-timing dependent plasticity. J. Neurosci. 26: 5604-5615.

Brette, R., Rudolph, M., Carnevale, T., Hines, M., Beeman, D., Bower, J.M., Diesmann, M., Morrison, A., Goodman, P.H., Harris, F.C., Zirpe, M., Natschläger, T., Pecevski, D., Ermentrout, B.,

Djurfeldt, M., Lanser, A., Rochel, O., Viéville, T., Muller, E., Davison, A.P., El Boustani, S. and Destexhe, A. (2007) Simulation of networks of spiking neurons : A review of tools and strategies. J. Comput. Neurosci. 23 : 349-398.

Pospischil, M., Toledo-Rodriguez, M., Monier, C., Piwkowska, Z., Bal, T., Fregnac, Y., Markram, H. and Destexhe, A.  (2008). Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons.  Biol. Cybernetics. 99: 427-441.

El Boustani, S. and Destexhe, A. (2009). A master equation formalism for macroscopic modeling of asynchronous irregular activity states. Neural Computation. 21: 46-100, 2009.

Davison, AP, Brüderle, D, Eppler, JM, Kremkow, J, Muller, E, Pecevski, D, Perrinet, L and Yger P (in press). PyNN: a common interface for neuronal network simulators. Frontiers in Neuroinformatics.

Field 3: Real-time Interface between Biological and Modelled neurons

Le Masson, G., Renaud-Le Masson, S., Debay, D. and Bal, T. (2002). Feedback inhibition controls spike transfer in hybrid thalamic circuits. Nature. 417 : 854-858.

Shu, Y., Hasenstaub, A. R., Badoual, M., Bal, T. and McCormick, D. A. (2003). Barrage of synaptic activity control the gain and sensitivity of cortical neurons. J. Neurosci. 23: 10388-10401.

Rudolph, M., Piwkowska, Z., Badoual, M., Bal, T. and Destexhe, A. (2004). A method to estimate synaptic conductances from membrane potential fluctuations. J. Neurophysiol. 91: 2884-2896.

Wolfart, J., Debay, D., Le Masson, G., Destexhe, A. and Bal, T. (2005). Synaptic background activity controls spike transfer from thalamus to cortex. Nature Neurosci. 8 : 1760-1767.

Brette, R., Piwkowska, Z., Monier, C., Rudolph, M., Fournier, J., Levy, M., Frégnac, Y., Bal, T. and Destexhe, A. (2008). High-resolution intracellular recordings using a real-time computational model of the electrode. Neuron. 379-391.

Pospischil, M., Piwkowska, Z., Bal, T. and Destexhe, A. (in press). Extracting synaptic conductances from single membrane potential traces. Neuroscience, in press.

Field 4: Physics applied to Neural Networks

Rudolph, M. and Destexhe, A. (2001). Correlation detection and resonance in neural systems with distributed noise sources.  Phys. Review Letters. 86: 3662-3665.

Bedard, C., Kröger, H. and Destexhe, A. (2006). Does the 1/f frequency-scaling of brain signals reflect self-organized critical states ? Phys. Review Letters. 97 :118102.

Rudolph, M. and Destexhe, A. (2006). A multichannel shot noise approach to describe synaptic background activity in neurons. Eur. Phys. J. B 52: 125-132.

Field 5: Interdisciplinary high profile reviews

Destexhe, A., Rudolph, M. and Paré, D. (2003). The high-conductance state of neocortical neurons in vivo. Nature Reviews Neurosci. 4: 739-751.

Destexhe, A. and Sejnowski, T. J. (2003). Interactions between membrane conductances underlying thalamocortical slow-wave oscillations. Physiol. Reviews. 83 : 1401-1453.

Destexhe, A. and Marder, E. (2004). Plasticity in single neuron and circuit computations (review).  Nature 431: 789-795.

Destexhe, A. and Contreras, D. (2006). Neural computations with stochastic network states (review). Science. 314 : 85-90.

Destexhe, A., Hughes, S.W., Rudolph, M. and Crunelli, V.  (2007). Are corticothalamic `up' states fragments of wakefulness?   Trends in Neurosciences.  30: 334-342.

Frégnac, Y., Blatow, M., Changeux, J.P., DeFelipe, J., Markram, H., Lansner, A., Maass, W., Markram, H., McCormick, D., Michel, C.M., Monyer, H., Szathmáry, E. and Yuste, R. (2006). Ups and downs cortical computation. In: "The Interface between Neurons and Global Brain Function Microcircuits” Dahlem Workshop Report 93. (Eds. Grillner, S. et al.) Cambridge, USA: The MIT Press, pp. 397-437.

Frégnac, Y., Rudolph, M., Davison, A.P. and Destexhe, A. (2007). Complexity and level hierarchy in neuronal networks. In: « Complexity in Biological networks », Editor F. Képes ; Complex Systems and Interdisciplinary Science Series, World Scientific. pp. 291-340.

Alonso-Nanclares, L., Anderson, S., Ascoli, G., Benavides-Piccione, R., Burkhalter, A., Buzsaki, G., Cauli, B., DeFelipe, J., Fairen, A., Feldmeyer, D., Fishel, G., Frégnac, Y., Freund, T. F., Fukuyi, K., Glarreta, M., Goldberg, J., Helmstaedter, M., Hensch, T., Hestrin, S., Kisvarday, Z., Lambolez, B., Lewis, D., McBain, C., Marin, O., Markham, H., Monyer, H., Muñoz, A., Petersen, C., Rockland, K., Rossier, H., Ruby, B., Somogyi, P., Staiger, J. F., Tamas, G., Thomson, A., Toledo-Rodriguez, M., Wang, X.-J., Wang, Y., West, D.  and  Yuste, R. (2008). Nomenclature of features of GABAergic interneurons of the cerebral cortex. Nature Neuroscience Reviews. 9: 557-568.